Searching an immunology-trained research fellow for a postdoc on immune-lymphatic crosstalk
The aim of our LYMIT-DIS European ERA-CVD project project is to identify and evaluate innovative treatments to limit the cardiac impact of metabolic syndrome and to prevent the transition from cardiac dysfunction to Heart Failure.
The postdoctoral research project will address the links between cardiac inflammation and lymphatics through investigation of the cross-talk that occurs between cardiac lymphatic endothelial cells (LEC) and immune cells in expeimental models of cardiac inflammation. The specific aspects that will be developed include a) assessment of chemokine ligand and receptor expression in cardiac LECs and immune cells infiltrating the heart; b) impact on lymphatic endothelium of immune cell-derived modulators (cytokines, lipids).
Required skills (what you need to know):
- Flow cytometric cell analysis and sorting, expression analyses (sequencing and single cell approaches a plus), immune cell culture, confocal microscopy
- General knowledge in immunology, special knowledge in chemokine signaling a clear plus
Offered skills (what we may teach you):
- Vascular biology including angiogenesis and lymphangiogenesis assays, cardiac physiology, histology & immunohistochemistry, whole mount staining & tissue clarification for 3D imaging, endothelial cell culture, epigenetics, drug delivery
- General knowledge in cardiovascular pathophysiology including gender aspects, skills in European project management & dissemination
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it. Deadline 20th of August 2018
The host laboratory, Inserm U1096, directed by Pr Vincent Richard https://insermu1096.fr/ is focused on evaluations of endothelial and cardiac dysfunctions with the aim to develop novel treatment strategies for cardiovascular diseases, especially Heart Failure.
Publication list
Members of the team
This email address is being protected from spambots. You need JavaScript enabled to view it., CR1 Inserm This email address is being protected from spambots. You need JavaScript enabled to view it., MD, PhD student
This email address is being protected from spambots. You need JavaScript enabled to view it., Technician
This email address is being protected from spambots. You need JavaScript enabled to view it., Lecturer (MCF)
Mahmoud Houssari, PhD student Manon Lefrancois, Master 2 student
This email address is being protected from spambots. You need JavaScript enabled to view it. Renet, Technician
This email address is being protected from spambots. You need JavaScript enabled to view it., PhD student
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